Medications Explainedby a Pharmacist

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GLP-1s, Diabetes & Weight Management

Jardiance and your kidneys

Aug 14, 2026 · Short · Empagliflozin

Jardiance works directly in your kidneys—so wouldn't that put MORE stress on them?

Surprisingly, in appropriate patients, the long-term effect can be protective.

Jardiance (empagliflozin) is an SGLT2 inhibitor. By changing how sodium and glucose are handled in the nephron, SGLT2 inhibitors can help reduce pressure and stress within the kidney's filtering system.

Kidney function may show a small initial change after starting treatment, but over time, Jardiance can help slow the progression of chronic kidney disease and reduce certain serious kidney and cardiovascular outcomes in appropriate patients.

That's one reason Jardiance is much more than simply a blood-sugar medication.

Want the full explanation of how Jardiance works, its heart and kidney benefits, side effects, dehydration, infections, and the important DKA warning? Watch my full Jardiance Explained video on the channel.

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