How metformin and GLP-1s work together

Many people think starting Ozempic or Mounjaro means stopping Metformin—but that's often not the case.

In fact, Metformin and GLP-1 medications work in different ways and are commonly used together to improve blood sugar control in people with type 2 diabetes.

• Metformin helps reduce glucose production in the liver and improves insulin sensitivity.

• GLP-1 medications like Ozempic and Mounjaro help regulate appetite, slow stomach emptying, and improve blood sugar control.

Together, they can be a powerful combination for many patients.

As a pharmacist, I'll explain how these medications work, who may benefit, and what patients should know before starting treatment.